Tissue hardening (lipohypertrophy)

What is lipohypertrophy?

  • This means changes, hardening of the subcutaneous fatty tissue.

What causes lipohypertrophy?

  • The re-use of damaged pen needles can lead to skin and tissue injuries.
  • This, together with frequent injections in so-called favourite sites, can lead to lipohypertrophy.

What are the consequences of lipohypertrophy?

  • Injections into hardened tissue affect insulin absorption making the insulin dose effectiveness difficult to calculate.
  • This can lead to unexplainable blood glucose fluctuations.

How can lipohypertrophy be avoided?

  • Change the injection site after every injection.
  • Use pen needles only 1x.
  • Recommendation: check injection sites regularly and consult your physician or diabetes advisor in case of conspicuous events.


Example of lipohypertrophy – Woman
Example of lipohypertrophy – Man

Lipohypertrophy can often be felt better than seen!